Statistical Approach for Gene Set Analysis with Trait Specific Quantitative Trait Loci
نویسندگان
چکیده
منابع مشابه
Efficient and Robust Statistical Methodologies for Quantitative Trait Loci Analysis
Quantitative genetic information has many applications in humans, plants and animals. Various statistical approaches have been developed to identify QTLs by using molecular markers, but most are parametrically based. The normality assumption of the underlying distributions greatly simplifies the testing and estimation problems. However, if this assumption is violated, false detection of a major...
متن کاملMultiple trait analysis of genetic mapping for quantitative trait loci.
We present in this paper models and statistical methods for performing multiple trait analysis on mapping quantitative trait loci (QTL) based on the composite interval mapping method. By taking into account the correlated structure of multiple traits, this joint analysis has several advantages, compared with separate analyses, for mapping QTL, including the expected improvement on the statistic...
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A number of recent genomewide surveys have found numerous QTL for gene expression, often with intermediate to high heritability values. As a result, there is currently a great deal of interest in genetical genomics--that is, the combination of genomewide expression data and molecular marker data to elucidate the genetics of complex traits. To date, most genetical genomics studies have focused o...
متن کاملMapping environment-specific quantitative trait loci.
Environment-specific quantitative trait loci (QTL) refer to QTL that express differently in different environments, a phenomenon called QTL-by-environment (Q × E) interaction. Q × E interaction is a difficult problem extended from traditional QTL mapping. The mixture model maximum-likelihood method is commonly adopted for interval mapping of QTL, but the method is not optimal in handling QTL in...
متن کاملQuantitative Trait Loci
Although the interval mapping method is widely used for mapping quantitative trait loci (QTLs), it is not very well suited for mapping multiple QTLs. Here, we present the results of a computer simulation to study the application of exact and approximate models for multiple QTLs. In particular, we focus on an automatic two-stage procedure in which in the first stage “important” markers are selec...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-19736-w